The process of inserting a single selected sperm directly into the cytoplasm of a mature egg, bypassing all the preliminary steps of sperm binding, is called as Intra Cytoplasmic Sperm Injection (ICSI). The specialty of ICSI I, men who are azospermic and who obtain 1 or 2 sperms by treatment or by testicular biopsy can have their own genetic child by this method. The main reason why this procedure is highly sought is due to the fact that it overcomes many barriers to fertilization and provides an additional option for patients in the treatment of their infertility.

The various barriers it overcomes, include, failed fertilization from repeated use of conventional IVF, severe male factor infertility, very low sperm counts and/or motility, high number of morphologically abnormal sperm, utilization of surgically retrieved sperm, use of frozen sperm when limited in number and quality.

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